PEER REVIEWED PUBLICATIONS - Link to PubMed

2018

• Kaushik V, Yakisich JS, Kumar A, Azad N, Iyer AKV. Ionophores: Potential Use as Anticancer Drugs and Chemosensitizers. Cancers (Basel). 2018 Sep 27;10(10). pii: E360. doi: 10.3390/cancers10100360. (PubMed)

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• Kaushik V, Yakisich JS, Way LF, Azad N, Iyer AKV. Chemoresistance of cancer floating cells is independent of their ability to form 3D structures: Implications for anticancer drug screening. J Cell Physiol. 2018 Sep 7. doi: 10.1002/jcp.27239. [Epub ahead of print] (PubMed)

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•  Guishard, A.F., Yakisich, J.S., Azad, N. and Iyer, A.K.V. (2018)  Translational Gap in Ongoing Clinical Trials for Glioma. J. Clin. Neurosci. 47:28-42 (PubMed)

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2017

• Yakisich, J.S., Kulkarni, Y., Azad, N. and Iyer, A.K.V. (2017)  Selective and irreversible induction of necroptotic cell death in lung tumorspheres by short-term exposure to Verapamil in combination with Sorafenib. Stem Cells Int. 2017:5987015 (PubMed)

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• Wright C, Iyer AK, Yakisich JS, Azad N. (2017) Anti-Tumorigenic Effects of Resveratrol in Lung Cancer Cells Through Modulation of c-FLIP. Curr Cancer Drug Targets. 17(7):669-680.  (PubMed)

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• Kulkarni YM, Yakisich JS, Azad N, Venkatadri R, Kaushik V, O'Doherty G, Iyer AKV. Anti-tumorigenic effects of a novel digitoxin derivative on both estrogen receptor-positive and triple-negative breast cancer cells.Tumour Biol. 2017 Jun;39(6):1010428317705331 (PubMed)

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• Kaushik, V.,  Azad, N., Yakisich, J.S., and Iyer, A.K.V. (2017) Antitumor effects of naturally occurring cardiac glycosides convallatoxin and peruvoside on human ER+ and triple-negative breast cancers. Cell Death Discov. 3:17009.(PubMed)

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• Yakisich, J.S., Azad, N., Kaushik, V.  and Iyer, A.K.V. (2017) Cancer Cell Plasticity: Rapid Reversal of Chemosensitivity and Expression of Stemness Markers in Lung and Breast Cancer Tumorspheres. J. Cell. Physiol. 232(9):2280-2286. (PubMed)

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• Yakisich, J.S., Azad, N., Kaushik, V., O'Doherty G,  and Iyer, A.K.V. (2017) Nigericin Decreases the Viability of Multidrug Resistant Cancer Cells and Lung Tumorspheres and Potentiates the Effects of Cardiac Glycosides. Tumour Biol. 2017  Mar; 39(3) :1010428317694310  (PubMed)

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• Venkatadri, R., Iyer, A.K.V., Ramesh, V., Wright, C.A., Castro, C.A., Yakisich, J.S., Azad, N. (2017). MnTBAP Inhibits Bleomycin-Induced Pulmonary Fibrosis by Regulating VEGF and Wnt Signaling. J. Cell. Physiol. 232:506-516. (PubMed)

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• Kaushik, V., Yakisich, J.S., Azad, N., Kulkarni, Y., Venkatadri, R., Wright, C., Rojanasakul, Y., Iyer, A. K., (2017) Anti-Tumor Effects of Cardiac Glycosides on Human Lung Epithelial Cancer Cells.  J. Cell. Physiol. In Press. (PubMed)

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2016

• Yakisich J.S., Venkatadri R, Azad N, Iyer AK. (2016) Chemoresistance of Lung and Breast Cancer Cells Growing Under Prolonged Periods of Serum Starvation. J. Cell. Physiol. In Press.  (PubMed)

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• Wright C, Iyer AK, Wang L, Wu N, Yakisich JS, Rojanasakul Y, Azad N. (2016) Effects of Titanium Dioxide Nanoparticles on Human Keratinocytes. Drug Chem Toxicol. 40:90-100.  (PubMed)

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• Farini, V.L., Camano, C.V., Ybarra, G., Viale, D.L., Vichera, G., Yakisich, J.S., Radrizzani, M. (2016) Improvement of bovine semen quality by removal of membrane damaged sperm cells with DNA aptamers and magnetic nanoparticles. J. Biotech. 229:31-41 (PubMed)

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• Venkatadri R, Muni T, Iyer AK, Yakisich JS, Azad N. (2016) Role of Apoptosis-related miRNAs in resveratrol-induced breast cancer cell death. Cell Death Dis. 7:e2104. (PubMed)

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• Ferraro, S., Astort, F., Yakisich, J.S., Tasat, D.R. (2016) Particulate matter cytotoxicity in cultured SH-SY5Y cells is modulated by Simvastatin: toxicological assessment for oxidative damage. Neurotoxicology 53:108-114. (PubMed)

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• Yakisich, J.S., Azad, N., Venkatadri, R., Kulkarni, Y., Wright, C., Kaushik, V.  and Iyer, A.K.V. (2016) Formation of Tumorspheres with Increased Stemness Without External Mitogens in a Lung Cancer Model. Stem Cells Int. 2016:5603135 (PubMed)

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• Orona, N.S., Ferraro, S.A., Astort, F., Morales, C., Brites, F., Boero, L., Tiscornia, G., Maglione, G.A., Saldiva, P.H., Yakisich, S., Tasat, D.R. (2016) Acute exposure to Buenos Aires air particles (UAP-BA) induces local and systemic inflammatory response in middle-aged mice: A time course study. Environ Pollut. 208(Pt A):261-270. (PubMed).

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• Yakisich, J.S., Azad, N., Venkatadri, R., Kulkarni, Y., Wright, C., Kaushik. V., O’Doherty, G.A., and Iyer, A.K.V. (2016) Digitoxin And Its Synthetic Analog MonoD Have Potent Antiproliferative Effects On Lung Cancer Cells And Potentiate The Effects Of Hydroxyurea And Paclitaxel. Oncol. Rep. 35: 878-886  (PubMed).

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• Kulkarni, Y.M., Dutta, S., Iyer, A. K., Venkatadri, R., Kaushik, V., Ramesh, V., Wright, C.A., Semmes, O. J., Yakisich, J.S. Azad, N. (2015) A Proteomics Approach to Identifying Key Protein Targets Involved in VEGF-Inhibitor Mediated Attenuation of Bleomycin-Induced Pulmonary Fibrosis. Proteomics (In Press)  (PubMed).

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2014

• Ma C., Zhao, G., Cruz, M.H., Siden, A., Yakisich, J.S. (2014) Translational gap in glioma research. Anticancer Agents Med. Chem. 8: 1110-1120. (PubMed).

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• Luo J., Zhou X., Yakisich J.S. (2014) Stemness and plasticity of lung cancer cells: paving the road for better therapy. Onco Targets Ther. 7:1129-34. Abstract (with link to free PDF)

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• Orona N.S., Astort F., Maglione G.A., Saldiva P.H.N., Yakisich J.S., Tasat D.R. (2014) Direct and Indirect Air Particle Cytotoxicity in Human Alveolar Epithelial Cells. Toxicol. In Vitro. 28:796-802 PubMed

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• Delwar, Z.M., Avramidis, D., Siden, A., Cruz, M., Paulsson, K., Yakisich, J. S. (2014) Low concentration of salinomycin prevents regrowth and partially depletes human glioma cells surviving high concentrations of alkylating agents. Clinical Cancer Drugs 1:72-77 . Abstract (with link to free PDF)

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• Wang, Z.,  Sun, H., Yakisich, J.S. (2014) Overcoming the blood brain barrier for chemotherapy: challenges, limitations and rising problems. Anticancer Agents Med. Chem. 8:1085-1093  PubMed

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• Yakisich, J.S. (2014) System models, assays and endpoint parameters to evaluate anticancer compounds during preclinical screening.  Current Med. Chem. 21:3985-98. PubMed

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2013

• Sun, H., Wang, Z., Yakisich, J.S. (2013) Natural products targeting autophagy via the PI3K/Akt/mTOR pathway as anticancer agents. Anticancer Agents Med. Chem. 13:1048-56. PubMed

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2012

•  Delwar, Z., Siden, A., Cruz, M., Yakisich, J.S.  (2012) Menadione:sodium orthovanadate  combination eliminates and inhibits migration of detached cancer cells. ISRN Pharmacology 2012:307102. PubMed.

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• Yakisich, J.S. (2012) An algorithm for the preclinical screening of anticancer drugs effective against brain tumors. ISRN Pharmacology. 2012:513580. PubMed.

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• Cruz, M., Siden , A, Calaf, G, Delwar,, Z.,  Yakisich, J.S.  (2012) The Stemness Phenotype model. ISRN Oncology, 2012:392647.  PubMed.

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• Delwar, Z., Avramidis, D., Follin, E., Hua, Y., Siden A., Cruz, M., Paulsson, K.M. , Yakisich, J.S. (2012) Cytotoxic effects of menadione:sodium orthovanadate combination on human glioma cells. Invest New Drugs. 30:1302-1310 PubMed

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• Yakisich, J.S.  (2012) Challenges and limitations of targeting cancer stem cells and/or the tumour microenvironment. Drugs and Therapy Studies. 2:e10. Abstract.

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2011

• Ferraro, S.A., Gallo, F.T., Yakisich, J.S.and Tasat D.R. (2011) Simvastatin pretreatment prevents ambient particle-induced lung injury in mice. Inhalation Toxicol. 23: 889-896 PubMed

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• Delwar, Z., Avramidis D., Siden, A., Cruz, M., Yakisich, J.S.  (2011) Depletion of drug-surviving glioma cells by a second phase treatment with low concentration of salinomycin. Drugs and Therapy Studies. 1:e7 Abstract

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• Delwar, Z., Vita, M.F. Siden, A., Cruz, M. and Yakisich, J.S. (2011) In vitro inhibition of topoisomerase II by reduced glutathione. Acta Biochim Polonica. 58: 265-267 PubMed

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• Vita, M.F, Nagachar, N., Avramidis,  D., Delwar, Z., Cruz, M., Siden A., Paulsson, K.M., Yakisich, J.S. (2011) Pankiller effect of prolonged exposure to menadione on glioma cells: potentiation by vitamin C. Invest New Drugs. 29: 1314-1320. PubMed. 

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2010

• Martin S., Fernandez-Alanis, E., Delfosse, V., Evelson, P., Yakisich, J.S., Saldiva, P.H., Tasat D.R. (2010) Low doses of urban air particles from Buenos Aires promote oxidative stress and apoptosis in mice lungs. Inhalation Toxicol. 22:1064-71 PubMed.

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• Cruz M., Siden A., Tasat, D.R., Yakisich, J.S. (2010) Are all Glioma Cells Cancer Stem Cells? J Cancer Sci Ther 2: 100-106

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• Yakisich, J.S., Vita, M., Tasat, D.R., Siden, A., and  Cruz, M. (2010) Strong inhibition of replicative DNA synthesis in the developing rat cerebral cortex and glioma cells by roscovitine. Invest New Drugs. 28:299-305. PubMed

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• Yakisich, J.S., Siden, A., and  Cruz, M. (2010) Ongoing DNA synthesis in the rat cerebral cortex is regulated by a proteolytic pathway independent of the proteasome and calpains. Invest New Drugs. 28:242-250. PubMed 

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2009

•  Avramidis, D., Cruz, M., Siden, A., Tasat, D.R., Yakisich, J.S. (2009)  Regrowth Concentration Zero (RC₀) as complementary endpoint parameter to evaluate compound candidates during preclinical drug development for cancer treatment. J. Cancer Sci. & Ther. 1, 19-24.

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• Yakisich, J.S., (2009) Theoretical basis for the measurement of small differences in the length of the cell cycle between two cell populations. The Open Biology Journal. 2:95-100.

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• Yakisich, J.S., Ohlsson Lindblom, I., Siden, A., and Cruz, M.H. (2009) Rapid inhibition of ongoing DNA synthesis in human glioma tissue by genistein  Oncol. Rep. 22: 569-574. PubMed

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2008

• Ostachuk, A., Evelson, P., Martin, S., Dawidowski, L., Yakisich, J.S. and Tasat, D.R. (2008) Age-related lung cell response to Urban Buenos Aires Air Particle soluble fraction. Environmen. Res. 107:170-7. PubMed

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2007 and before

• Mohammad, M.M., Donti, T.R., Yakisich, J.S., Smith, A.G. and G.M. Kapler. (2007) Tetrahymena ORC contains a ribosomal RNA fragment that participates in rDNA origin recognition. EMBO J. 26:5048-5060  Pubmed 

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• Yakisich, J.S*, Sandoval, P*., Morrison, T., and G.M. Kapler. (2006) TIF1 activates the intra-S phase checkpoint response in the diploid micronucleus and amitotic polyploid macronucleus of Tetrahymena . Mol. Biol Cell 17:5185-5197. * First co-authors. PubMed

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• Yakisich, J.S. and Kapler, G.M. (2006) Deletion of the Tetrahymena thermophila rDNA replication fork barrier region disrupts macronuclear rDNA excision and creates a fragile site in the micronuclear genome. Nucleic Acid Res. 34:620-634 Pubmed.

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• Morrison, T.L., Yakisich, J.S., Cassidy-Hanley, D. and Kapler, G.M. (2005) TIF1 Represses rDNA Replication Initiation, but Promotes Normal S Phase Progression and Chromosome Transmission in Tetrahymena. Mol. Biol. Cell 16 2624-2635 PubMed 

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• Smith, J.J.*, Yakisich, J.S.* Kapler, G.M., Cole, E.S., and Romero, D.P. (2004) A ß-Tubulin Mutation Selectively Uncouples Nuclear Division and Cytokinesis in Tetrahymena thermophila. Eukaryot. Cell 3: 1217-1226. *First Co-authors. PubMed

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• Yakisich, J.S. and Kapler, G.M. (2004) The effect phosphoinositide 3-kinase inhibitors on programmed nuclear degradation in Tetrahymena thermophila and fate of surviving nuclei . Cell Death Differ. 11: 1146-1149. PubMed

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• Vitali, L.,Yakisich, J.S., Vita, M.F., Fernandez, A., Settembrini, L., Siden, A., Cruz, M., Carminatti, H., Casas, O. and Idoyaga Vargas, V. (2002) Roscovitine inhibits ongoing DNA synthesis in human cervical cancer. Cancer Lett. 180: 7-12. PubMed

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• Yakisich, J.S., Siden, A., Eneroth, P., and Cruz, M. (2001) Disulfiram is a potent in vitro inhibitor of DNA topoisomerases. Biochem. Biophys. Res. Commun. 289: 586-590. PubMed

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• Yakisich, J.S., Boethius, J., Walsteed, L., Ohlsson Lindblom, I., Idoyaga Vargas, V., Siden, A., and Cruz, M. (1999) Inhibition of DNA synthesis in human gliomas by roscovitine. Neuroreport 10: 2563-2567. PubMed

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• Yakisich, J.S., Idoyaga Vargas, V., Eneroth, P., Siden, A. and Cruz, M. (1999) Early effects of protein kinase modulators on DNA synthesis in rat cerebral cortex. Exp. Neurol. 159: 164-176. PubMed

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• Yakisich, J.S., Siden, A., Idoyaga Vargas, V., Eneroth, Peter and Cruz, M. (1998) Fast and sensitive method for simultaneous measurement of cell proliferation rate and drug sensitivity in rat cerebral cortex. Exp. Neurol. 151:194-202. PubMed

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• Yakisich, J.S., Siden, A., Idoyaga Vargas, V., Eneroth, Peter and Cruz, M. (1998) Early inhibition of DNA synthesis in the developing rat cerebral cortex by the purine analogues olomoucine and roscovitine. Biochem. Biophys. Res. Commun. 243, 674-677. PubMed

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• Castagnino, G., Yakisich, J.S., Iacono, R., Berria, M.I. and Idoyaga Vargas, V. (1995) Growth inhibition of Herpes Simplex Virus Type I in Calphostin-C treated astrocytes. Intervirology 38:332-338. PubMed

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• Yakisich, J.S., Radrizzani, M. and Idoyaga Vargas, V. (1994) Examination of the natural protein substrates affected by Staurosporine in the developing cerebral cortex. Neurosci. Lett. 180:17-20. PubMed

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• EDITORIALS

• Chen, J., Yakisich, J.S. (2014) Emerging concepts and therapeutic strategies for the treatment of brain tumors. Anticancer Agents Med. Chem. 8:1063-1064. PubMed

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• Tasat, D.R., Yakisich, J.S. (2012 ) Expanding the pleiotropic effects of statins:  attenuation of air pollution-induced inflammatory response.  Am. J. Physiol. Lung Cell. Mol. Physiol. 15;303(8):L640-1. PubMed

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• Yakisich, J.S. (2011) Preclinical anticancer drugs screening:  perspectives from emerging models of glioma biology. Drugs & Therapy Studies. 1:e1. Link

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